Publications

Clicking on the title of the paper will send you to the article on the publisher's website and a subscription may be required to view the article. For some papers, a free version is available. For these papers, I have included a link to a free version of the article - either a preprint or Pubmed Central (PMC). 

1. Langley, J., Bennett, I., and Hu, X. Examining iron-related off-target binding effect of 18F-AV1451 in the cortex of Aβ+ individuals. European Journal of Neuroscience. 60(1):3614-3628, 2024. 

2. Bennett, I., Langley, J., Sun, A., Solis, K., Seitz, A., and Hu, X.  Locus Coeruleus Contrast and Diffusivity: Effects of Age and Relations to Memory. Scientific Reports, 14:15372. (Link to Preprint)  

3. Qi, B., Chen, H., Langley, J., Badie, B., Hu, X., and Sheng, J. An MRI-Conditional Flexible Endoscopic Robot with a Hydraulic Tendon-Driven Actuation System. Journal of Medical Robotics Research, 4:2440003, 2024.

4. Hussain S., Menchaca, I., Shalcy, M., Yaghoubi, K., Langley, J., Seitz, A., Hu, X., and Peters, M. Locus coeruleus integrity predicts east of attaining and maintaining neural states of arousal. Brain Research Bulletin, 202:110733, 2023. (Link to Preprint)

5. Huddleston, D., Chen, X., Hwang, K., Langley, J., Tripathi, R., Tucker, K., McKay, J., Hu, X., and Factor, S. Neuromelanin-sensitive MRI correlates of cognition, motor function, and aging in Parkinson’s disease with freezing of gait. Frontiers in Dementia, 2:1215505, 2023. (Link to Preprint) 

6. Hwang, K.*, Langley, J.*, Tripathi, R., Hu, X., and Huddleston, D. In vivo detection of substantia nigra and locus coeruleus volume loss in Parkinson’s disease using neuromelanin-sensitive MRI: Replication in two cohorts. PLOS One 18(3):e0282684, 2023. *Equal Contributions. (Link to Preprint; Link to manuscript in PMC)

7. Hussain, S., Langley, J., Seitz, A., Peters, M., and Hu, X. A novel hidden Markov approach to studying dynamic functional connectivity states in human neuroimaging. Brain Connectivity, 13(3):154-163, 2023. (Link to Preprint)

8. Langley, J., Hwang, K., Hu, X., and Huddleston, D. Nigral volumetric and microstructural measures in individuals with scans without evidence of dopaminergic deficit. Frontiers in Neuroscience. 16:1048945, 2022. (Link to Preprint; Link to manuscript in PMC)

9. Langley, J., Hussain, S., Huddleston, D., Bennett, I., and Hu, X. Impact of locus coeruleus and its projections on memory in aging. Brain Connectivity, 12(3):223-233, 2022. (Link to Preprint; Link to manuscript in PMC) 

10. Reardon, A., Li, K., Langley, J., and Hu, X. Subtyping autism spectrum disorder via joint modelling of clinical and connectomic profiles. Brain Connectivity, 12(2):193-205, 2022.

11. Langley, J., Huddleston, D., and Hu, X. Nigral diffusivity, but not free water, correlates with iron content in Parkinson’s disease.  Brain Communications, 3(4):fcab251, 2021. (Link to Preprint; Link to manuscript in PMC)

12. Franco, C., Petok, J., Langley, J., Hu, X., and Bennett, I. Implicit associative learning relates to basal ganglia gray matter integrity in young and older adults. Behavioural Brain Research, 397:112950, 2021. (Link to manuscript in PMC) 

13. Langley, J., Huddleston, D., Crosson, B., Song, D., Factor, S., and Hu, X. Multimodal assessment of nigrosomal degeneration in Parkinson’s disease. Parkinsonism and Related Disorders, 80:102-107, 2020. (Link to Preprint; Link to manuscript in PMC)

14. Hackney, M., Bay, A., Jackson, J., Nocera, J., Krishnamurthy, V., Crosson, B., Evatt, M., Langley, J., Cui, X., McKay, L., and Huddleston, D. Rationale and design of the PAIRED trial: partnered dance aerobic exercise as a neuroprotective, motor, and cognitive intervention in Parkinson’s disease. Frontiers in Neurology, 11:943, 2020. (Link to manuscript in PMC)

15. He, N.*, Langley, J.*, Chen, S., Huang, P., Ling, H., Zhang, Y., Yan., F., and Hu, X. Increased iron-deposition in lateral-ventral substantia nigra pars compacta: A promising neuroimaging marker for Parkinson's disease. NeuroImage: Clinical, 28:102391, 2020. *Equal Contributions. (Link to manuscript in PMC)

16. Langley, J., Hussain, S., Flores, J., Bennett, I., and Hu, X. Characterization of age-related microstructural changes in locus coeruleus and substantia nigra pars compacta. Neurobiology of Aging, 87(1):89-97, 2020. (Link to Preprint; Link to manuscript in PMC) 

17. Langley, J.*, He, N.*, Huddleston, D., Ling, H., Yan, F., Factor, S., and Hu, X. Reproducible detection of nigral iron deposition in two Parkinson’s disease cohorts. Movement Disorders, 34(3):416-420, 2019, *Equal Contributions. (Link to manuscript in PMC)

18. Huddleston, D., Langley, J., Dusek, P., He, N., Faraco, C., Crosson, B., Factor, S., and Hu, X. Imaging parkinsonian pathology in substantia nigra with MRI. Current Radiology Reports, 6(4):15, 2018.

19. Sulzer, D., Cassidy, C., Horga, G., Kang, U., Fahn, S., Casella, L., Pezzoli, G., Langley, J., Hu, X., Zucca, F., Isaias, I., Zecca, L. Magnetic resonance imaging (MRI) detection of neuromelanin provides a biomarker for Parkinson’s disease. npj Parkinson’s Disease, 4:11, 2018. (Link to manuscript in PMC)

20. He, N.*, Langley, J.*, Huddleston, D., Ling, H., Liu, C., Yan, F., and Hu, X. Improved neuroimaging atlas of the dentate nucleus. The Cerebellum, 16(5-6):951-956, 2017 *Equal Contributions.

21. Huddleston, D., Langley, J., Sedlacik, J., Boelmans, K., Factor, S., and Hu, X. MRI detection of lateral-ventral tier nigral degeneration in Parkinson’s disease. Human Brain Mapping, 38(5):2627-2634, 2017. (Link to manuscript in PMC)

22. Langley, J., Sedlacik, J., Huddleston, D., Boelmans, K., and Hu, X. Parkinson’s disease related increase of T2* weighted hypointensity in substantia nigra pars compacta. Movement Disorders, 32(3): 441-449, 2017.

23. Langley, J., Huddleston, D., Liu, C., Chen, X., and Hu, X. Reproducibility of locus coeruleus and substantia nigra volume measurements in neuromelanin sensitive MRI. Magnetic Resonance Materials in Physics, Biology and Medicine (MAGMA), 30(2): 121-125, 2017.

24. He, N., Huang, P., Ling, H., Langley, J., Liu, C., Ding, B., Huang, J., Xu, H., Zhang, Y., Zhang. Z., Hu, X., Chen, S., and Yan, F. Dentate nucleus iron deposition is a potential biomarker for tremor-dominant Parkinson’s disease. NMR in Biomedicine, 30(4):e3554, 2017.  (Link to manuscript in PMC)

25. Langley, J., Huddleston, D., Merritt, M., Chen, X., McMurray, R., Silver, M., Factor, S., and Hu, X. Diffusion tensor imaging of the substantia nigra revisited. Human Brain Mapping, 37(7):2547:2556, 2016. (Link to manuscript in PMC)

26. Chen, S., Langley, J., Chen, X., and Hu, X. Spatiotemporal modeling of fMRI resting-state spontaneous activity with a Gaussian Hidden Markov Model. Brain Connectivity, 6(4):326-335, 2016.

27. Ji, B., Li, Z., Li L., Langley, J., Shen, H., and Hu, X. Dynamic thalamus parcellation based on resting-state fMRI data. Human Brain Mapping, 37(3):954-967, 2016. (Link to manuscript in PMC)

28. Xue, S., Yang, H., Qiao, J. Pu, F., Jiang, J., Hubbard, K., Hekmatarya, K., Langley, J., Salarian, M., Long, R., Bryant, R., Hu, X., Grossniklaus, H., Liu, Z. R., Yang, J. A protein MRI contrast agent with unprecedented metal selectivity and sensitivity for liver cancer imaging. Proceedings of the National Academy of Sciences, 112(21): 6607-6612, 2015. (Link to manuscript in PMC)

29. Langley, J., Huddleston, D., Chen, X., Sedlacik, J., Zachariah, N., and Hu, X. A multicontrast approach for comprehensive imaging of substantia nigra. Neuroimage, 112(1): 7-13, 2015. (Featured on cover; Link to manuscript in PMC)

30. Li, K., Langley, J., Li, Z., and Hu, X. Connectomic Profiles for individualized resting state networks and ROIs. Brain Connectivity, 5(2): 69-79, 2015. (Link to manuscript in PMC)

31. Chen, X., Huddleston, D., Langley, J., Ahn, S., Barnum, C., Factor, S., Levy, A., and Hu, X. Simultaneous imaging of locus coeruleus and substantia nigra with a quantitative neuromelanin MRI approach. Magnetic Resonance Imaging, 32(9): 1301-1306, 2014

32. Langley, J., Potter, W.M., Phipps, C., Feng, H., and Zhao, Q. A self-reference PRF-shift MR thermometry method utilizing the phase gradient. Physics in Medicine and Biology, 56(24): N307-N320, 2011.

33. Zhao, Q., Langley, J., Lee, S., and Liu, W. Positive contrast technique for detection and quantification of superparamagnetic iron oxide nanoparticles in magnetic resonance imaging. NMR in Biomedicine, 24(5): 464-472, 2011.

34. Langley, J., Liu, W., Jordon, E.K., Frank, J.A., and Zhao, Q. Quantification of SPIO nanoparticles in vivo using the finite perturber method. Magnetic Resonance in Medicine, 65(5): 1461-1469, 2011. (Link to manuscript in PMC)

35. Faraco, C., Unsworth, N., Langley, J., Terry, D., Zhang, D., Liu, T., and Miller, S. Complex span tasks and hippocampal recruitment during working memory. Neuroimage, 55(2): 773-787, 2011.

36. Wang, L., Langley, J., and Zhao, Q. Susceptibility quantification in MRI using modified conjugate gradient least square method. Proc. SPIE 7961, Medical Imaging: Physics of Medical Imaging, 79613T, 2011 

37. Zhao, Q., Langley, J., Lee, J., Abell, J., and Zhao, Y. Bioimaging and biospectra analysis by means of independent component analysis: experimental results. Proc. SPIE 8058, Independent Component Analyses, Wavelets, Neural Networks, Biosystems, and Nanoengineering IX, 80580E, 2011

38. Langley, J., Brice, R., and Zhao, Q. A recursive approach to the moment-based phase unwrapping method. Applied Optics, 49(16): 3096-3101, 2010.

39. McCully, K., Turner, T., Langley, J., and Zhao, Q. The reproducibility of measurements of intramuscular magnesium concentrations. Dynamic Medicine, 8:5, 2009.

40. Zhao, Q., Langley, J., Faraco, C., and Miller, LS. Correction of susceptibility-induced distortion in diffusion tensor imaging with a moment-based phase unwrapping method. International Journal of Functional Informatics and Personalized Medicine, 2(2):136-149, 2009.

41. Langley, J. and Zhao, Q. A model-based phase unwrapping algorithm using Gegenbauer polynomials. Physics in Medicine and Biology, 54(17): 5237-5252, 2009.

42. Langley, J. and Zhao, Q. Unwrapping MR phase maps with Chebyshev polynomials, Magnetic Resonance Imaging, 27(9): 1293-1301, 2009. 

Clicking on the title will send you to the preprint on whatever preprint server the paper was submitted to. I usually try to post to arxiv or medrxiv. 

1. Beach, P., Kurra, N., Hwang, K., Langley, J., Hu, X., and Huddleston, D. Locus coeruleus volume is reduced in early Parkinson disease-related orthostatic hypotension. 

2. Langley, J., Dara, S., Bennett, I., and Hu, X. Striatal tau burden is increased in APOE-e4+ mild cognitive impairment. 

3. Langley, J., Hwang, K., Huddleston, D., and Hu, X. Nigral volume loss in prodromal, early, and moderate Parkinson's disease. 

1. Langley, J., Huddleston, D.E., and Hu, X. Detecting Parkinsonian degeneration in lateral-ventral tier of substantia nigra pars compacta with MRI. In “The Neuroscience of Parkinson’s Disease: Genetics, Neurology, Behavior, and Diet”. Chapter 20, pages 313-325, 2020